刘美丽，副教授，博导，北京航空航天大学生物与医学工程学院骨干教师，教育部力生物学与生物力学重点实验室，入选2011年北京航空航天大学“蓝天科研新星”。北京市生物医学工程高精尖创新中心副研究员。2008年入职以来，在樊瑜波教授团队工作，负责细胞及组织工程实验室。多年来，从事神经损伤后的再生修复研究，从力生物学和神经生物学结合，研究神经突起的导向生长的分子机制，从纳米导电材料、力学牵拉、电刺激、磁场以及磁性粒子等方面深入探究神经元对其响应的分子作用机制，从细胞实验到动物在体实验，验证了牵拉在神经修复中的作用。主持国家自然科学基金项目3项，近年来发表第一作者或通讯作者SCI论文15余篇。教学方面负责本科生课程《免疫学》，《实验动物学》，其中《免疫学》入选2018年“双百”工程优质课程，参与本科生课程《临床生物化学、血液学及检验》，负责研究生课程《神经生物学》，参与研究生课程《组织细胞培养》，每年完成教学110学时左右。同时担任多名本科生和研究生的毕业导师，积极服务于本科生的学术指导、大学生活适应等辅导工作。

主持的科研项目情况：

项目名称：Sema-Plexin信号通路在牵张力调控神经轴突导向生长中的作用及机制的研究，项目编号：31971238，国家自然科学基金面上项目，执行年限：2020.01-2023.12，主持，在研

项目名称：DCC受体及其RhoGTPase/MAPK信号通路在周期性牵张调控神经导向生长中的作用机制研究，

项目编号：31470901 ，国家自然科学基金面上项目，执行时间：2015.01-2018.12 主持，完成

项目名称：牵张对神经突起导向生长相关分子Netrin 1和Septin 7表达的影响及机制研究，项目编号：31100666，国家自然科学基金青年基金项目，执行年限：2012.01-2014.12 主持，完成

【相关成果目录】

（1）发表第一作者或通讯作者SCI论文情况：

Meili Liu#,Gang Zhou^#, Wei Song, Ping Li,  Haifeng Liu, Xufeng Niu, Yubo Fan*. Effect of nano-hydroxya  patite on the axonal guidance growth of rat cortical neurons. Nanoscale. 2012 4(10):3201-7. SCI, IF₂₀₁₉ =6.895

Meili Liu^#, Xufeng Niu^#, Gang Zhou^#, Zhengtai Jia, Ping Li, Yubo Fan*. Potential Effect of Mechano Growth Factor E-domain Peptide on Axonal Guidance Growth in Primary Cultured Cortical Neurons of Rats，Journal of Tissue Engineering and Regenerative Medicine. 2018, 12:70-79 , SCI,  IF₂₀₁₉ = 3.078

Meili Liu, Gang Zhou, Yongzhao Hou, Gang Kuang, Zhengtai Jia, Ping Li, Yubo Fan*. Effect of nano-hydroxyapatite-coated magnetic nanoparticles on axonal guidance growth of rat dorsal root ganglion neurons. Journal of Biomedical Materials Research Part A, 2015, 103(9):3066-71  SCI，IF₂₀₁₉ =3.525

Meili Liu^#, Wei Song^#, Ping Li, Yan Huang, Xianghui Gong, Gang Zhou, Xiaoling Jia, Lisha Zheng, Yubo Fan*.Galanin Protects against Nerve Injury after Shear Stress in Primary Cultured Rat Cortical Neurons. PloS one, 2013,8(5):e63473.SCI, IF₂₀₁₉ =2.740

Meili Liu，Jianqiang Wen，Yubo Fan* . Potential Protection of Green Tea Polyphenols Against 1800 MHz Electromagnetic Radiation-Induced Injury on Rat Cortical Neurons, Neurotoxicity Research, 2011，20（3）：270-276 SCI， IF₂₀₁₉ =2.992

Jianqiang Wen^#*，Meili Liu^#. Piezoelectric Ceramic (PZT) Modulates Axonal Guidance Growth of Rat Cortical Neurons via RhoA, Rac1, and Cdc42 Pathways, Journal of Molecular Neuroscience, 2014，52, 323-330. SCI, IF₂₀₁₉ =2.678

Meili Liu^#, Jianjun Wen^#, Xuefang Xu, Deming Zhao*. Neurotoxic Effect of the Complex of the Ovine Prion Protein (OvPrPC) and RNA on the Cultured Rat Cortical Neurons. Neurochemical Research 2011; 36:1863-1869. SCI, IF₂₀₁₉ =3.038

Meili Liu，Longchuan Yu*. Potential protection of green tea polyphenols against ultraviolet irradiation-induced injury on rat cortical neurons. Neuroscience Letters, 2008, 444: 236-239. SCI, IF₂₀₁₉ =2.272

Meili Liu, Yuxing Li, Xiangmei Zhou, Deming Zhao*. Copper (II) Inhibits in Vitro Conformational Conversion of Ovine Prion Protein Triggered by Low pH, Journal of Biochemistry，2008，143 (3):333-337. SCI, IF₂₀₁₉ =2.274

Meili Liu, Shan Yu, Jianmin Yang, Xiaomin Yin, and Deming Zhao*. RNA and copper (Ⅱ) chloride induced the conformational changes of the recombinant ovine prion protein PrP 23-256, Molecular and Cellular Biochemistry. 2007, 294: 197–203. SCI, IF₂₀₁₉ =2.795

Meili Liu^#, Zhengtai Jia^#, Xiongfu Xiao, Zhifa Zhang, Ping Li, Gang Zhou*, Yubo Fan*. 2018. Carboxylated graphene oxide promoted axonal guidance growth by activating Netrin-1/DCC signaling in rat primary cultured cortical neurons. 2018, Journal of Biomedical Materials Research Part A, 106(6):1500-1510 . SCI, IF₂₀₁₉ =3.525.

Meili Liu, Chuanwei Yin, Zhengtai Jia, Kun Li, Zhifa Zhang, Yuchen Zhao, Xianghui Gong, Ping Li *, Yubo Fan*. Protective effect of moderate exogenous electrical field stimulation on activating Netrin-1/DCC expression against mechanical stretch-induced injury in spinal cord neurons. 2018, Neurotoxity Research. 34[41]:285-294. SCI, IF₂₀₁₇ =2.992.

Meili Liu, Chongquan Huang, Zhengtai Jia, Zhijun Zhao, Xiongfu Xiao, Anqing Wang, Ping Li, Xiali Guan, Gang Zhou* and Yubo Fan*. Promotion of Neuronal Guidance Growth by Aminated Graphene Oxide via Netrin-1/Deleted in Colorectal Cancer Signaling. ACS Chemical Neuroscience. 2020, 11, 604−614. SCI, IF₂₀₁₉ =4.486.

Haifeng Liu#, Yuqing Wang#, Yi Yang, Anqing Wang, Chongquan Huang, Zhijun Zhao, Ping Li, Meili Liu *, Yubo Fan*. Aligned graphene/silk fibroin conductive fibrous scaffolds for guiding neurite outgrowth in rat spinal cord neurons[J]. Journal of Biomedical Materials Research Part A, 2020. DOI：10.1002/jbm.a.37031. SCI, IF₂₀₁₉ =3. 525.

Wei Song#, Meili Liu#, ZhiJun Zhao, ChongQuan Huang, JunWei Xu, AnQing Wang, Ping Li* & Yu-Bo Fan*. SIRT1 Inhibits High Shear Stress-Induced Apoptosis in Rat Cortical Neurons[J]. Cellular and Molecular Bioengineering, 2020. DOI：10.1007/s12195-020-00623-2. SCI, IF₂₀₁₉ =1.720.

Meili Liu, Chongquan Huang, Zhijun Zhao, Anqing Wang, Ping Li, Yubo Fan, Gang Zhou*, Nano-hydroxyapatite(n-HA) Involved in The Regeneration of Rat Nerve Injury Triggered by Overloading Stretch.2019, Medicine in Novel Technology and Devices. DOI：10.1016/j.medntd.2019.100022.

（2）通讯作者发表中文核心期刊论文

1）贾正泰，张志发，赵钰琛，刘美丽*；netrin-1在纳米材料修复神经损伤中的作用机制研究进展，中国药理学与毒理学杂志，2017,31（12）：1201-1207（通讯作者）中文核心期刊

（3）参加会议发表的第一作者或通讯作者论文

1) 刘美丽，周 钢，樊瑜波。周期性牵张对石墨烯诱导的神经突起导向生长研究 ，医用生物力学, 2015(10):182。

2）贾正泰、匡刚、刘美丽*。周期性牵张对脊髓神经元突起导向生长的影响 ，医用生物力学, 2015(10), 278-279。

3）刘美丽, 赵志军, 殷传伟, 黄重荃, 樊瑜波。牵张应力诱导神经轴突导向分子受体DCC表达的研究，医用生物力学，2018，8（33）：108。

4) 殷传伟，赵志军，黄重荃，张志发，赵钰琛，樊瑜波，刘美丽*。力生长因子MGF对神经轴突导向分子Netrin-1表达的研究，医用生物力学，2018，8（33）：279。

5) 贾正泰，殷传伟，牛旭锋，樊瑜波， 刘美丽*。力生长因子诱导神经突起导向分子DCC表达的研究，2017，中国生物材料大会，会议摘要（通讯作者）