张靖，男，博士学位，北京航空航天大学生物医学工程高精尖创新中心，教授；“***青年人才奖”获得者；中国科学院“卓越青年科学家人才计划”入选者；中国科学院“创新促进会”成员。2002年6月和2005年6月于哈尔滨理工大学分别获得自动控制学士学位和计算机应用技术硕士学位，2009年于中国科学院自动化研究所获得模式识别与智能系统博士学位。于2009年7月入职中国科学院北京基因组所任助理研究员，2014年1月升任副研究员。2014年获得中国科学院“卓越青年科学家人才”，入选中国科学院青年创新促进会，获得2014年度“***青年人才奖”。2015年7月入职美国哥伦比亚大学（Columbia University）任Associate Research Scientist。2019年入职北京航空航天大学任教授。

多年来一直从事数据挖掘、机器学习、人工智能的研究以及它们在生物医药领域的应用。 主要集中在如何开发、应用机器学习方法从充满噪声的高通量、高纬度的基因组数据中提取特征， 挖掘出有用信息，以解决早期胚胎发育、肿瘤发生发展、多肽疫苗研究方面的实际问题。在最顶级国际 SCI 学 术刊物上，诸如 CELL，Nature，Cell Research， Annals of Oncology， Neuro-Oncology，Nucleic Acid Research， National Science Review 等，发表 SCI 期刊论文 30 篇。先后作为项目主持人承担国家自然科学基金，中国科学院卓越青年科学家人才，中国科学院创新促进会人才等课题。作为大数据挖掘与机器学习的Investigator，2017年在美国哥伦比亚大学成功申请了Children's Tumor Foundation的资助用于研究脑瘤。2019年获得青年学者项目支持。多次受邀出席国际会议作基因组大数据挖掘与机器学习的报告。

现主要开展 1. 开发新的深度学习方法，研究肿瘤发生发展，预后，免疫相关科学问题； 2. 应用机器学习方法挖掘全基因组学数据，研究免疫系统与肿瘤发生发展之间的交互作用关系；3. 开发、应用新的机器学习方法研究鉴定多肽疫苗；4. 构建转基因动物模型， 从分子生物学的机制层面研究肿瘤免疫、多肽疫苗相关的科学问题。5. 生物医学诊疗平台的开发。

发表论文：

2020年

Lin Li, Ting Sun, Yufei He, Wendong Li, Yubo Fan#, Jing Zhang#. Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2.Virus Research，2020，Oct 15; 288:198082 (#通讯作者)

Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Zixuan Xiao, Yubo Fan#, Jing Zhang#. Spike protein-based epitopes predicted against SARS-CoV-2 through literature mining. Medicine in Novel Technology and Devices. 2020, Dec; 8:100048. (#通讯作者)

Francesca Pia Caruso,Luciano Garofano,Fulvio D'Angelo,Kai Yu,Fuchou Tang,Jinzhou Yuan,Jing Zhang,Luigi Cerulo,Stefano M Pagnotta,Davide Bedognetti,Peter A Sims,Mario Suvà,Anna Lasorella,Xiao-Dong Su,Antonio Iavarone,Michele Ceccarelli. A map of tumor-host interactions in glioma at single-cell resolution. Gigascience, 2020, 9(10): giaa109 

2019年

Jing Zhang, Francesca P. Caruso, Jason K. Sa, Sune Justesen, Do-Hyun Nam, Peter Sims, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone. The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival. Communications Biology. 2019,2:135.

Xiaocui Xu*,Guoqiang Li*,Congru Li*,Jing Zhang*,Qiang Wang*,David K Simmons,Xuepeng Chen,Naveen Wijesena,Wei Zhu,Zhanyang Wang,Zhenhua Wang,Bao Ju,Weimin Ci,Xuemei Lu,Daqi Yu,Qian-fei Wang,Neelakanteswar Aluru,Paola Oliveri,Yong E Zhang,Mark Q Martindale,Jiang Liu#. Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 2019, nwz064.（*共同第一）

Jason K. Sa, Seung Won Choi, Junfei Zhao, Yeri Lee, Jing Zhang, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-II Lee, Antonio Iavarone, Raul Rabadan, Do-Hyun Nam. Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations. International Journal of Cancer, 2019, 144 (12):3023-3030.

Yu Ren,Yun-fei Wang,Jing Zhang,Qi-xue Wang,Lei Han,Mei Mei,Chun-sheng Kang. Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2. Clinical Epigenetics, 2019, 11(29).

Faping Shen,Chunyan Song,Yunmian Liu,Jing Zhang,SonyaWei Song. IGFBP2 Promotes Neural Stem Cell Maintenance and Proliferation Differentially Associated with Glioblastoma Subtypes. Brain Research, 2019, 1704: 174-186.        

2018年

Qixue Wang, Jinquan Cai, Chuan Fang, Chao Yang, Junhu Zhou, Yanli Yan, Yunfei Wang, Yansheng Li, Xiangqi Meng, Kai Zhao, Kaikai Yi, Sijing Zhang, Jianning Zhang, Chuanlu Jiang#, Jing Zhang#, Chunsheng Kang#. Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-B pathway. Theronostics,2018,8(17):4733-4749. (#通讯作者）

Veronique Frattini, Stefano Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano, Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature, 2018 Jan 11; 553(7687):222-227. 

Fulvio D’Angelo, Michele Ceccarelli, Tala, Luciano Garofano, Jing Zhang, Veronique Frattini, Francesca P Caruso, Genevieve Lewis, Kristin D. Alfaro, Luc Bauchet, Giulia Berzero, David Cachia, Mario Cangiano, Laurent Capelle, John de Groot, Francesco DiMeco, Fracois Ducray, Walid Farah, Gaetano Finocchiaro, Stephane Goutagny, Carlos Kamiya Matsuoka, Cinzia Lavarino, Hugues Loiseau, Veronique Lorgis, Carlo E Marras, Ian McCutcheon, Do-Hyun Nam, Susanna Ronchi, Veronica Saletti, Romuald Seizeur, John Slopis, Mariona Sunol, Fanny Vandenbos, Pascale Varlet, Dominiqu Vidaud, Colin Watts, David E Reuss, Seung-Ki Kim, Viviane Tabar, David Meyronet, Karima Mokhtari, Hector Salvador, Krishna P. Bhat, Marica Eoli, Marc Sanson, Anna Lasorella, Antonio Iavarone. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nature Medicine, 2018, 25(1):176-187. 

2016年

Wang Yunfang,Qin Jinhua,Wang Shuyong,Zhang Wencheng,Duan Jialei,Zhang Jing,Wang Xin,Yan Fang,Chang Mingyang,Liu Xiaofang,Feng Bo,Liu Jiang,Pei Xuetao. Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. Cell stem cell, 2016, 19(4): 449-461.  

2015年

Chen Ke*,Zhang Jing*,Guo Zhongqiang*,Ma Qin,Xu Zhengzheng,Zhou Yuanyuan,Xu Ziying,Li Zhongwu,Liu Yiqiang,Ye Xiongjun,Li Xuesong,Yuan Bifeng,Ke Yuwen,He Chuan,Zhou Liqun,Liu Jiang,Ci Weimin. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Research, 2015, 26: 103-118.(*共同第一）

Zou Dong,Sun Shixiang,Li Rujiao,Liu Jiang,Zhang Jing#,Zhang Zhang#. MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Research, 2015, 43(Database issue): D54-D58.(#通讯作者）

Wang Lu,Zhang Jun,Duan Jialei,Gao Xinxing,Zhu Wei,Lu Xingyu,Yang Lu,Zhang Jing,Li Guoqiang,Ci Weimin,Li Wei,Zhou Qi,Aluru Neel,Tang Fuchou,He Chuan,Huang Xingxu,Liu Jiang. Programming and inheritance of parental DNA methylomes in mammals. Cell, 2015, 157(4).

Li Guoqiang,Ci Weimin,Karmakar Subhradip,Chen Ke,Dhar Ruby,Fan Zhixiang,Guo Zhongqiang,Zhang Jing,Ke Yuwen,Wang Lu,Zhuang Min,Hu Shengdi,Li Xuesong,Zhou Liqun,Li Xianghong,Calabrese MatthewF,Watson EdmondR,Prasad SandipM,Rinker-Schaeffer Carrie,Eggener ScottE,Stricker Thomas,Tian Yong,Schulman BrendaA,Liu Jiang,White KevinP.. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell, 2015, 25(4): 455-468.             

Han Haibo,Du Yantao,Zhao Wei,Li Sheng,Chen Dongji,Zhang Jing,Liu Jiang,Suo Zhenhe,Bian Xiuwu,Xing Baocai,Zhang Zhiqian. PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. Nature Communications, 2015, 8271.

Zhou Xuan,Ren Yu,Zhang Jing,Zhang Chuanbao,Zhang Kailiang,Han Lei,Kong Lingping,Wei Jianwei,Chen Luyue,Yang Jingxuan,Wang Qixue,Zhang Jianning,Yang Yuqi,Jiang Tao,Li Min,Kang Chunsheng. HOTAIR is a therapeutic target in glioblastoma. Oncotarget, 2015, 6: 8353-8365            

2013年

Jiang Lan*,Zhang Jing*,Wang Jing-Jing*,Wang Lu,Zhang Li,Li Guoqiang,Yang Xiaodan,Ma Xin,Sun Xin,Cai Jun,Zhang Jun,Huang Xingxu,Yu Miao,Wang Xuegeng,Liu Feng,Wu Chung-I,He Chuan,Zhang Bo,Ci Weimin,Liu Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. Cell, 2013, 153(4): 773-784. (*共同第一）

Zhang Wei*,Zhang Jing*,Yan Wei,You Gan,Bao Zhaoshi,Li Shouwei,Kang Chunsheng,Jiang Chuanlu,You Yongping,Zhang Yuxiang,Chen ClarkC,Song SonyaWei,Jiang Tao. Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer, 2013, 119(4): 814-824. (*共同第一）

Zhang Jun-Xia*,Zhang Jing*,Yan Wei*,Wang Ying-Yi,Han Lei,Yue Xiao,Liu Ning,You Yong-Ping,Jiang Tao,Pu Pei-Yu,Kang Chun-Sheng. Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro-Oncology, 2013, 15(3): 712-719. (*共同第一）    

Lin Yi,Zhang Guozhen,Zhang Jing,Gao Guangzu,Li Min,Chen Yong,Wang Jiangfei,Li Guilin,Song Sonya-Wei,Qiu Xiaoguang,Wang Yunjie,Jiang Tao. A panel of four cytokines predicts the prognosis of patients with malignant gliomas. Journal of Neuro-Oncology, 2013, 114(2): 199-208.  

2012年 

Zhang Wei*,Zhang Jing*,Hoadley Katherine,Kushwaha Deepa,Ramakrishnan Valya,Li Shouwei,Kang Chunsheng,You Yongping,Jiang Chuanlu,Song SonyaWei,Jiang Tao,Chen Clark C.. MiR-181d: Predictive glioblastoma biomarker that downregulates MGMT expression. Neuro-Oncology, 2012, 14(6): 712-719.(*共同第一）

Li Yuchen*,Jiang Tao*,Zhang Jing*,Zhang Bin,Yang Wei,You Gan,Xu Kaiyu,Wu Jing,Luo Chenghua,Song SonyaW. Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Annals of Oncology, 2012, 23(9): 2415-2422.(*共同第一）  

2011年

Tao Yong,Ruan Jue,Yeh Shiou-Hwei,Lu Xuemei,Wang Yu,Zhai Weiwei,Cai Jun,Ling Shaoping,Gong Qiang,Chong Zecheng,Qu Zhengzhong,Li Qianqian,Liu Jiang,Yang Jin,Zheng Caihong,Zeng Changqing,Wang Hurng-Yi,Zhang Jing,Wang Sheng-Han,Hao Lingtong,Dong Lili,Li Wenjie,Sun Min,Zou Wei,Yu Caixia,Li Chaohua,Liu Guojing,Jiang Lan,Xu Jin,Huang Huanwei,Li Chunyan,Mi Shuangli,Zhang Bing,Chen Baoxian,Zhao Wenming,Hu Songnian,Zhuang Shi-Mei,Shen Yang,Shi Suhua,Brown Christopher,White Kevin P.,Chen Ding-Shinn,Chen Pei-Jer,Wu Chung-I. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A, 2011, 108(29): 12042-12047. 

2010年  

Fan Ming,Liu Bing,Jiang Tianzi,Jiang Xingpeng,Zhao Huizhi,Zhang Jing. Meta-analysis of the Association between the Monoamine Oxidase-A Gene and Mood Disorders. Psychiatric Genetics, 2010, 20(1): 1-7.

2009年    

Zhang Jing,Liu Bing,Jiang Xingpeng,Zhao Huizhi,Fan Ming,Fan Zhenjie,Lee J.Jack,Jiang Tao,Jiang Tianzi,Song SonyaWei. A Systems Biology-Based Gene Expression Classifier of Glioblastoma Predicts Survival with Solid Tumors. PLoS ONE, 2009, 4(7): e6274.

Zhao Huizhi,Wang Dong,Liu Bing,Jiang Xingpeng,Zhang Jing,Fan Ming,Fan Zhenjie,Chen Ying,Song SonyaWei,Gao Wei,Jiang Tianzi,Cui Qinghua. Recombination rates of human microRNA. Biochem Biophys Res Commun, 2009, 379(3): 702-705. 

2008年

Zhang Jing,Jiang Tianzi,Liu Bing,Jiang Xingpeng,Zhao Huizhi. Systematic benchmarking of microarray data feature extraction and classification. International Journal of Computer Mathematics, 2008, 85(5): 803-811. 

Jiang Xingpeng,Liu Bing,Jiang Jiefeng,Zhao Huizhi,Fan Ming,Zhang Jing,Fan Zhenjie,Jiang Tianzi. Modularity in the genetic disease-phenotype network [Journal]. FEBS Lett, 2008, 582(17): 2549-2554.    

2006年

Liu Bing,Jiang Tianzi,Ma Songde,Zhao Huizhi,Li Jun,Jiang Xingpeng,Zhang Jing. Exploring candidate genes for human brain diseases from a brain-specific gene network. Biochem Biophys Res Commun, 2006, 349(4): 1308-1314. 

2005年

Jing Xu, Zhang Jing. Hotspot clustering for ad hoc network. Proceedings of International Conference on Wireless Communications, Networking and Mobile Computing, 2005, 2.